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J Med Food. 2016 Mar;19(3):228-37. doi: 10.1089/jmf.2015.3547. Epub 2016 Feb 5.

The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research.

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1 Department of Anatomy and Cell Biology and Neurology, College of Medicine, Chung-Ang University , Seoul, Korea.
2 Famenity Biomedical Research Center, Famenity, Inc. , Gyeonggi, Korea.
3 Natural Pharmaceutical R&D Center, Naturesense, Inc. , Gyeonggi, Korea.
4 Department of Physiology, College of Medicine, Chung-Ang University , Seoul, Korea.
5 Department of Neurosurgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine , Seoul, Korea.
6 Department of Internal Medicine, The Catholic University of Korea College of Medicine , Gyeonggi, Korea.
7 Department of Food Science and Nutrition, College of Natural Science, Dankook University , Chungnam, Korea.
8 Department of Urology, College of Medicine, Chung-Ang University , Seoul, Korea.
9 Division of Immunobiology, Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine , Gyeonggi, Korea.
10 Department of Food Science and Nutrition, College of Natural Science, Hallym University , Gangwon, Korea.


Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.


Kupperman's Index; MS-10; colpoxerosis; menopause; ovariectomized rat

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