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Int J Mol Sci. 2016 Feb 2;17(2). pii: E202. doi: 10.3390/ijms17020202.

Molecular Mechanisms of Nickel Allergy.

Author information

1
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. m.saito@tokushima-u.ac.jp.
2
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. arakaki.r@tokushima-u.ac.jp.
3
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. aki.yamada@tokushima-u.ac.jp.
4
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. tsunematsu@tokushima-u.ac.jp.
5
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. yasusei@tokushima-u.ac.jp.
6
Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan. ishimaru.n@tokushima-u.ac.jp.

Abstract

Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy.

KEYWORDS:

DC; DTH; Ni; T cell; TLR; TSLP; metal allergy

PMID:
26848658
PMCID:
PMC4783936
DOI:
10.3390/ijms17020202
[Indexed for MEDLINE]
Free PMC Article

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