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Eur J Nutr. 2017 Apr;56(3):1095-1104. doi: 10.1007/s00394-016-1159-3. Epub 2016 Feb 5.

Effects of vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomised clinical trials.

Author information

1
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
2
Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
3
College of Medicine, University of Al-Mustansiriyah, Baghdad, Iraq.
4
Elsie Widdowson Laboratory, MRC Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.
5
School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, UK.
6
Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. mario.siervo@ncl.ac.uk.
7
Elsie Widdowson Laboratory, MRC Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL, UK. mario.siervo@ncl.ac.uk.

Abstract

BACKGROUND:

In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D supplementation on EF and to examine whether the effect size was modified by health status, study duration, dose, route of vitamin D administration, vitamin D status (baseline and post-intervention), body mass index (BMI), age and type of vitamin D.

METHODS:

We searched the Medline, Embase, Cochrane Library and Scopus databases from inception until March 2015 for studies meeting the following criteria: (1) RCT with adult participants, (2) vitamin D administration alone, (3) studies that quantified EF using commonly applied methods including ultrasound, plethysmography, applanation tonometry and laser Doppler.

RESULTS:

Sixteen articles reporting data for 1177 participants were included. Study duration ranged from 4 to 52 weeks. The effect of vitamin D on EF was not significant (SMD: 0.08, 95 % CI -0.06, 0.22, p = 0.28). Subgroup analysis showed a significant improvement of EF in diabetic subjects (SMD: 0.31, 95 % CI 0.05, 0.57, p = 0.02). A non-significant trend was found for diastolic blood pressure (β = 0.02; p = 0.07) and BMI (β = 0.05; p = 0.06).

CONCLUSIONS:

Vitamin D supplementation did not improve EF. The significant effect of vitamin D in diabetics and a tendency for an association with BMI may indicate a role of excess adiposity and insulin resistance in modulating the effects of vitamin D on vascular function. This remains to be tested in future studies.

KEYWORDS:

Cardiovascular risk; Flow-mediated dilation; Forearm blood flow; Nitric oxide; Pulse wave velocity; Vitamin D

PMID:
26848580
DOI:
10.1007/s00394-016-1159-3
[Indexed for MEDLINE]

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