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Nutr Cancer. 2016;68(2):208-13. doi: 10.1080/01635581.2016.1134598. Epub 2016 Feb 4.

Bladder Cancer is Associated with Low Plasma 25-hydroxyvitamin D Concentrations in Tunisian Population.

Author information

1
a UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, Faculty of Sciences of Tunis, University of Tunis El Manar , Tunis , Tunisia.
2
b Department of Urology , Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.
3
c UR05/08-08, LR99ES11, Department of Biochemistry, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.

Abstract

Little evidence suggests an impact of vitamin D on bladder cancer risk in Caucasians. This study aimed to investigate association of plasma 25-hydroxyvitamin D (25-OHD) with urothelial bladder cancer (UBC) risk in Tunisians. A case-control study included 250 patients with UBC and 250 healthy controls. Plasma 25-OHD was assessed by a competitive chemiluminescence immunoassay. Vitamin D deficiency and insufficiency were defined as 25-OHD <30 nmol/L and 30 to 49.99 nmol/L, respectively. Logistic regression models adjusting for gender, age, smoking status, duration of smoking, occupational exposure, and season were applied. Vitamin D deficiency (50.4% vs. 34.8%; P < 0.001) and insufficiency (40.4% vs. 26.8%; P < 0.001) were more frequent in patients than controls. Multivariate analysis showed that UBC is associated with vitamin D deficiency [odd-ratio (95% confidence interval), 3.71 (1.76-7.80); P = 0.001] and vitamin D insufficiency [2.65 (1.40-5.01); P = 0.003]. Other predictors of UBC were female gender, tobacco use, smoking duration, and occupational exposure. Plasma 25-OHD concentrations are low in Tunisian patients with UBC. These findings support experimental and epidemiological evidence of protective role of vitamin D against UBC but could not ascertain causal relationship. Further prospective studies and clinical trials are warranted to check causality.

PMID:
26847528
DOI:
10.1080/01635581.2016.1134598
[Indexed for MEDLINE]

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