Format

Send to

Choose Destination
Chron Respir Dis. 2016 Feb;13(1):75-81. doi: 10.1177/1479972315620746.

Preclinical lung disease in early rheumatoid arthritis.

Author information

1
Department of Pneumology, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain a_roblesperez@hotmail.com.
2
Servei de Diagnòstic per la Imatge El Prat (SDPI El Prat), Department of Radiology, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain.
3
Department of Pneumology, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain.
4
Department of Pneumology, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain CIBER de Enfermedades Respiratorias (CIBERES).
5
Department of Rheumatology, Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain.

Abstract

Early detection and treatment of lung disease in patients with rheumatoid arthritis (RA) may ameliorate disease progression. The objectives of this study were to investigate the frequency of asymptomatic lung abnormalities in early RA patients and the potential association of positive RA blood reactive biomolecules with lung involvement. A prospective observational study was performed in a cohort of patients with early RA (joint symptoms < 2 years) without respiratory symptoms, who were included in a screening program for lung disease with a baseline chest radiograph (CR) and complete pulmonary function tests (PFTs). In those patients with lung abnormalities on the CR or PFTs, a high-resolution chest computed tomography scan (HRCT) was performed. We included 40 patients (30 women). Altered PFTs were detected in 18 (45%) of these patients. These cases had a diffusion lung transfer capacity of carbon monoxide (DLCO) of <80% of predicted, without a significant reduction in the forced vital capacity. The HRCT detected abnormalities in 11 of the 18 patients. Diffuse bronchiectasis was the main finding. An inverse correlation between the anti-citrullinated peptide antibody (ACPA) levels and DLCO was found. Asymptomatic lung disease is present in up to 45% of early RA patients and can be determined by PFTs and ACPA levels.

KEYWORDS:

Arthritis; autoantibodies; lung diseases; multidetector computed tomography; respiratory function tests; rheumatoid

PMID:
26846584
PMCID:
PMC5720204
DOI:
10.1177/1479972315620746
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center