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ACS Chem Biol. 2016 Mar 18;11(3):669-80. doi: 10.1021/acschembio.5b00999. Epub 2016 Feb 15.

Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.

Conrad RJ1,2,3, Ott M1,2,3.

Author information

1
Gladstone Institute of Virology and Immunology , San Francisco, California 94158, United States.
2
Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California , San Francisco, California 94158, United States.
3
Department of Medicine, University of California , San Francisco, California 94158, United States.

Abstract

Persistent viral infections are widespread and represent significant public health burdens. Some viruses endure in a latent state by co-opting the host epigenetic machinery to manipulate viral gene expression. Small molecules targeting epigenetic pathways are now in the clinic for certain cancers and are considered as potential treatment strategies to reverse latency in HIV-infected individuals. In this review, we discuss how drugs interfering with one epigenetic pathway, protein acetylation, perturb latency of three families of pathogenic human viruses-retroviruses, herpesviruses, and papillomaviruses.

PMID:
26845514
PMCID:
PMC5477850
DOI:
10.1021/acschembio.5b00999
[Indexed for MEDLINE]
Free PMC Article

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