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ACS Chem Biol. 2016 Apr 15;11(4):842-9. doi: 10.1021/acschembio.5b00800. Epub 2016 Feb 17.

Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.

Author information

1
University of California San Francisco , Institute of Neurodegenerative Diseases, 675 Nelson Rising Lane, San Francisco, California 94143, United States.

Abstract

Many psychiatric drugs modulate the nervous system through multitarget mechanisms. However, systematic identification of multitarget compounds has been difficult using traditional in vitro screening assays. New approaches to phenotypic profiling in zebrafish can help researchers identify novel compounds with complex polypharmacology. For example, large-scale behavior-based chemical screens can rapidly identify large numbers of structurally diverse and phenotype-related compounds. Once these compounds have been identified, a systems-level analysis of their structures may help to identify statistically enriched target pathways. Together, systematic behavioral profiling and multitarget predictions may help researchers identify new behavior-modifying pathways and CNS therapeutics.

PMID:
26845413
PMCID:
PMC5067259
DOI:
10.1021/acschembio.5b00800
[Indexed for MEDLINE]
Free PMC Article

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