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Cornea. 2016 Apr;35(4):471-6. doi: 10.1097/ICO.0000000000000771.

Relationship Between Tissue Unscrolling Time and Endothelial Cell Loss.

Author information

1
*Ophthalmic Consultants of Boston, Boston, MA; †Devers Eye Institute, Portland, OR; ‡Massachusetts Eye and Ear Infirmary, Boston, MA; and §Lions VisionGift, Portland, OR.

Abstract

PURPOSE:

To assess the relationship between intraoperative unscrolling time of the donor Descemet membrane endothelial keratoplasty (DMEK) tissue and 6-month postoperative endothelial cell loss (ECL), and to determine whether donor age, scroll tightness, and the presence of an S stamp are related to unscrolling time.

METHODS:

Ninety-three consecutive uncomplicated DMEK surgeries performed on eyes with Fuchs endothelial dystrophy using our standardized technique (ie, prestripped tissue with or without a premarked S stamp from our eye bank, overstripping the recipient, Straiko glass injector, no-touch tap technique, and bubble of 20% SF6 gas) were evaluated. Intraoperative unscrolling times and 6-month endothelial cell densities were measured and analyzed.

RESULTS:

Sixty-nine cases comprised the study cohort. The median unscrolling time was 4 minutes (range: 0.8-17.5 minutes), and the median ECL was 26.9% (range: -4.3% to 80.0%). There was no relationship between unscrolling time and ECL at 6 months by the Pearson correlation coefficient (r = -0.02, P = 0.89). Younger donor age, tighter scrolls, and absence of an S stamp had no correlation with longer unscrolling times (all P > 0.05). Only 2 of 4 cases of iatrogenic primary graft failure had unscrolling times available for analysis; in this limited sample, there was no association between iatrogenic primary graft failure and unscrolling time.

CONCLUSIONS:

Once the DMEK tissue is safely in the anterior chamber, surgeons need not rush the "DMEK dance" because longer unscrolling times may not endanger the endothelium.

PMID:
26845314
DOI:
10.1097/ICO.0000000000000771
[Indexed for MEDLINE]

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