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Breast J. 2016 May;22(3):282-6. doi: 10.1111/tbj.12567. Epub 2016 Feb 4.

Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is Histologically Similar but Immunohistochemically and Molecularly Distinct from Well-differentiated Liposarcoma of Soft Tissue.

Author information

1
University of Michigan, Ann Arbor, Michigan.

Abstract

Malignant phyllodes tumor (PT) infrequently displays heterologous differentiation, and when present is most often liposarcomatous. We identified five cases of malignant PT with regions identical to well-differentiated liposarcoma (WDLS) of soft tissue and evaluated them for MDM2 and CDK4 gene expression and amplification using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. Despite indistinguishable morphology all cases of malignant PT with WDLS-like liposarcomatous differentiation were negative for MDM2 and CDK4 IHC and FISH, supporting different underlying pathogenesis.

KEYWORDS:

CDK4; MDM2; liposarcoma; phyllodes tumor

PMID:
26843318
DOI:
10.1111/tbj.12567
[Indexed for MEDLINE]

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