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PLoS One. 2016 Feb 3;11(2):e0148009. doi: 10.1371/journal.pone.0148009. eCollection 2016.

Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training.

Author information

1
Department of Internal Medicine, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, Virginia, United States of America.
2
Center for Gerontology & Department of Human Development, Virginia Tech, Blacksburg, Virginia, United States of America.
3
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States of America.
4
Department of Psychology, Virginia Tech, Blacksburg, Virginia, United States of America.

Abstract

PURPOSE:

To determine if prediabetes phenotype influences improvements in glucose homeostasis with resistance training (RT).

METHODS:

Older, overweight individuals with prediabetes (n = 159; aged 60±5 yrs; BMI 33±4 kg/m2) completed a supervised RT program twice per week for 12 weeks. Body weight and composition, strength, fasting plasma glucose, 2-hr oral glucose tolerance, and Matsuda-Defronza estimated insulin sensitivity index (ISI) were assessed before and after the intervention. Participants were categorized according to their baseline prediabetes phenotype as impaired fasting glucose only (IFG) (n = 73), impaired glucose tolerance only (IGT) (n = 21), or combined IFG and IGT (IFG/IGT) (n = 65).

RESULTS:

Chest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both p<0.05). Waist circumference (-1.0%; pre 109.3±10.3 cm, post 108.2±10.6 cm) and body fat (-0.6%; pre 43.7±6.8%, post 43.1±6.8%) declined, and lean body mass (+1.3%; pre 52.0±10.4 kg, post 52.7±10.7 kg) increased following the intervention. Fasting glucose concentrations did not change (p>0.05) following the intervention. However, 2-hr oral glucose tolerance improved in those with IGT (pre 8.94±0.72 mmol/l, post 7.83±1.11 mmol/l, p<0.05) and IFG/IGT (pre 9.66±1.11mmol/l, post 8.60±2.00 mmol/l) but not in those with IFG (pre 6.27±1.28mmol/l, post 6.33± 1.55 mmol/l). There were no significant changes in ISI or glucose area under the curve following the RT program.

CONCLUSIONS:

RT without dietary intervention improves 2-hr oral glucose tolerance in individuals with prediabetes. However, the improvements in glucose homeostasis with RT appear limited to those with IGT or combined IFG and IGT.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT01112709.

PMID:
26840904
PMCID:
PMC4739703
DOI:
10.1371/journal.pone.0148009
[Indexed for MEDLINE]
Free PMC Article

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