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PLoS One. 2016 Feb 3;11(2):e0148189. doi: 10.1371/journal.pone.0148189. eCollection 2016.

Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.

Author information

  • 1Biostatistics core, George Washington University Medical Faculty Associates, Washington, DC, United States of America.
  • 2George Washington University School of Medicine, Washington, DC, United States of America.
  • 3Division of cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
  • 4Kaiser Permanente Division of Research, Oakland, CA, United States of America.
  • 5Division of Renal diseases and Hypertension, George Washington University School of Medicine, Washington, DC, United States of America.
  • 6Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States of America.
  • 7Bridgeport Hospital, Bridgeport, CT, United States of America.
  • 8Harvard Medical School, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • 9Temple Heart and Vascular Center, Philadelphia, PA, United States of America.
  • 10Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
  • 11Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
  • 12Wake Forest University School of Medicine, Winston-Salem, NC, United States of America.
  • 13National Institute of Diabetes and Digestive and Kidney Diseases, Division of Kidney, Urologic and Hematologic Diseases, Bethesda, MD, United States of America.
  • 14Division of Cardiology, George Washington University School of Medicine, Washington, DC, United States of America.

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD.

PMID:
26840403
PMCID:
PMC4739587
DOI:
10.1371/journal.pone.0148189
[PubMed - indexed for MEDLINE]
Free PMC Article
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