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Molecules. 2016 Jan 29;21(2):165. doi: 10.3390/molecules21020165.

A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid.

Author information

1
Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. rajusures@gmail.com.
2
Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. almansor@ksu.edu.sa.
3
Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. anatarajan@ksu.edu.sa.
4
Central Laboratory, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. altafamu@gmail.com.
5
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain. josecm@farm.ucm.es.
6
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. raju.ranjithkumar@gmail.com.
7
School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia. ohasnah@usm.my.

Abstract

The microwave-assisted three-component reactions of 3,5-bis(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones, acenaphthenequinone and cyclic α-amino acids in an ionic liquid, 1-butyl-3-methylimidazolium bromide, occurred through a domino sequence affording structurally intriguing diazaheptacyclic cage-like compounds in excellent yields.

KEYWORDS:

diazaheptacyclic cage compounds; ionic liquid; microwave-assisted synthesis; multicomponent reactions

PMID:
26840282
DOI:
10.3390/molecules21020165
[Indexed for MEDLINE]
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