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Mult Scler Int. 2015;2015:681289. doi: 10.1155/2015/681289. Epub 2015 Dec 29.

The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis.

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Department of Neuro-Ophthalmology, The National Hospital for Neurology and Neurosurgery, Box 93, Queen Square, London WC1N 3BG, UK.


Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.

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