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J Korean Med Sci. 2016 Feb;31(2):202-7. doi: 10.3346/jkms.2016.31.2.202. Epub 2016 Jan 14.

The Effects of Rituximab on Lipids, Arterial Stiffness and Carotid Intima-Media Thickness in Rheumatoid Arthritis.

Author information

1
Department of Instrumental and Ultrasound Diagnostics, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
2
Department of Systemic Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
3
Department of Early Arthritis, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
4
Department Immunology and Molecular Biology, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.
5
V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.

Abstract

The aim of the study was to examine lipid profiles, arterial stiffness (AS), carotid intima-media thickness (cIMT), in 55 women with RA without overt cardiovascular disease (–°VD) treated with rituximab (RTX).The following parameters were recorded before and 24 weeks after RTX therapy (2 infusions of 500 or 1,000 mg RTX intravenously, fortnightly): plasma total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, DAS 28-ESR, serum C-reactive protein (CRP), RF IgM, AS (SI - stiffness index, RI - reflection index) by digital volume pulse contour analysis (Micro Medical, UK), and common cIMT by high-resolution B-mode carotid ultrasound. Based on the European League Against Rheumatism (EULAR) criteria, patients were divided into two groups: 1) moderate/good response to RTX therapy after 24 weeks (41 patients, 75%), 2) no response to RTX therapy (14 patients, 25%). Effective RTX therapy resulted in 9% increase in TC, 23% increase in HDL-C and 14% decrease in atherogenic index, 57% decrease in SI and 24% decrease in RI. We observed a 9% decrease of cIMTmax at 24 weeks. The improvement of cardiovascular parameters was accompanied by statistically significant decreases of CRP, ESR, RF IgM and DAS 28 in group 1 (P < 0.05). There were not significant changes in lipid profile, AS parameters, and cIMT in group 2. Two infusions of RTX in case of moderate/good EULAR effect of therapy exerted favorable effects on lipid profile, AS and cIMT in women with RA without overt CVD.

KEYWORDS:

Arterial Stiffness; Carotid Atherosclerosis; Lipids; Rheumatoid Arthritis; Rituximab

PMID:
26839473
PMCID:
PMC4729499
DOI:
10.3346/jkms.2016.31.2.202
[Indexed for MEDLINE]
Free PMC Article

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