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Head Neck. 2016 Apr;38 Suppl 1:E1969-73. doi: 10.1002/hed.24361. Epub 2016 Feb 2.

Pattern of lymph node metastasis in hypopharyngeal squamous cell carcinoma and indications for level VI lymph node dissection.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Head and Neck Cancer Hospital, Hallym University, College of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

The purpose of this study was to determine the incidence, risk factors, and prognostic significance of level VI lymph node metastases from hypopharyngeal squamous cell carcinoma (SCC).

METHODS:

A retrospective review of 68 previously untreated patients with hypopharyngeal SCC who underwent level VI node dissection was performed.

RESULTS:

Level VI lymph node metastases occurred in 27.9% of patients. The occult metastasis rate of level VI node was 14.3%. Patients with level VI metastasis had significantly lower disease-specific (55.1% vs 26.3%) and overall survival rates (73.5% vs 31.6%). Level VI lymph node metastasis was significantly correlated with regional recurrence (83.7% vs 63.2%) and distant metastasis (67.3% vs 47.4%). Multivariate analysis revealed that pyriform sinus apex invasion (odds ratio [OR] = 5.106) was an independent factor for level VI nodal metastasis.

CONCLUSION:

Level VI lymph nodes should be removed in patients with pyriform sinus apex invasion, especially in those with advanced nodal disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: E1969-E1973, 2016.

KEYWORDS:

hypopharyngeal carcinoma; paratracheal lymph node; prognosis; surgery

PMID:
26835610
DOI:
10.1002/hed.24361
[Indexed for MEDLINE]

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