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J Exp Med. 2016 Feb 8;213(2):143-53. doi: 10.1084/jem.20151677. Epub 2016 Feb 1.

Expanding the antimalarial toolkit: Targeting host-parasite interactions.

Author information

1
Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, England, UK jean.langhorne@crick.ac.uk.
2
Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.

Abstract

Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.

PMID:
26834158
PMCID:
PMC4749928
DOI:
10.1084/jem.20151677
[Indexed for MEDLINE]
Free PMC Article

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