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Acta Paediatr. 2016 Jun;105(6):576-86. doi: 10.1111/apa.13350. Epub 2016 Mar 8.

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.

Author information

1
Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
2
Department of Pediatrics, Institute of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.
3
Department of Neonatology, University Hospital, Karolinska Institute, Stockholm, Sweden.
4
Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
5
Department of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.
6
Genova Neonatal Intensive Care Unit, Instituto Pediatrico Giannina Gaslini, Genova, Italy.
7
University of Cambridge, Cambridge, UK.
8
Faculty of Academy of Medical Sciences, Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
9
Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

CONCLUSION:

There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

KEYWORDS:

Development; Foetus; Insulin-like growth factor 1; Metabolism; Preterm infant

PMID:
26833743
PMCID:
PMC5069563
DOI:
10.1111/apa.13350
[Indexed for MEDLINE]
Free PMC Article

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