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Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495.

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu Y1,2, Day FR3, Gustafsson S4,5, Buchkovich ML6, Na J7, Bataille V8,9, Cousminer DL10, Dastani Z11, Drong AW12, Esko T13,14,15,16, Evans DM17,18, Falchi M9,19, Feitosa MF20, Ferreira T12, Hedman ÅK4,5,12, Haring R21,22, Hysi PG9, Iles MM23, Justice AE24, Kanoni S25,26, Lagou V12,27, Li R11, Li X28, Locke A29, Lu C30, Mägi R12,13, Perry JR3, Pers TH15,16,31,32,33, Qi Q34, Sanna M9,19, Schmidt EM35, Scott WR36,37, Shungin D38,39,40, Teumer A41,42, Vinkhuyzen AA43, Walker RW1,2, Westra HJ44,45,46, Zhang M47, Zhang W36,37, Zhao JH3, Zhu Z43, Afzal U36,37, Ahluwalia TS31,48,49,50, Bakker SJ51, Bellis C52, Bonnefond A53,54,55, Borodulin K56, Buchman AS57, Cederholm T58, Choh AC59, Choi HJ60, Curran JE61, de Groot LC62, De Jager PL44,63,64, Dhonukshe-Rutten RA62, Enneman AW65, Eury E53,54,55, Evans DS66, Forsen T67, Friedrich N21, Fumeron F68,69,70,71, Garcia ME72, Gärtner S73, Han BG74, Havulinna AS56, Hayward C75, Hernandez D76, Hillege H77, Ittermann T41, Kent JW52, Kolcic I78, Laatikainen T56,79,80, Lahti J81,82, Mateo Leach I77, Lee CG83,84, Lee JY74, Liu T85,86, Liu Y87, Lobbens S53,54,55, Loh M36,88, Lyytikäinen LP89,90, Medina-Gomez C65,91,92, Michaëlsson K93, Nalls MA76, Nielson CM94,95, Oozageer L37, Pascoe L96, Paternoster L18, Polašek O78,97, Ripatti S10,26,98, Sarzynski MA99, Shin CS100, Narančić NS101, Spira D102,103, Srikanth P94,95, Steinhagen-Thiessen E102,103, Sung YJ104, Swart KM105,106, Taittonen L107,108, Tanaka T109, Tikkanen E10,98, van der Velde N65, van Schoor NM105,106, Verweij N77, Wright AF75, Yu L57, Zmuda JM110, Eklund N56, Forrester T111, Grarup N31, Jackson AU29, Kristiansson K10,56, Kuulasmaa T112, Kuusisto J112,113,114, Lichtner P115, Luan J3, Mahajan A12, Männistö S56, Palmer CD14,15, Ried JS116, Scott RA3, Stancáková A117, Wagner PJ10,56, Demirkan A118, Döring A119,120, Gudnason V121,122, Kiel DP123,124, Kühnel B116,120,125, Mangino M9, Mcknight B126,127,128, Menni C9, O'Connell JR129, Oostra BA118, Shuldiner AR129,130, Song K131, Vandenput L132, van Duijn CM91,118,133, Vollenweider P134, White CC30, Boehnke M29, Boettcher Y135,136, Cooper RS137, Forouhi NG3, Gieger C116,120,125, Grallert H120,125,138, Hingorani A139, Jørgensen T140,141,142, Jousilahti P56, Kivimaki M143, Kumari M143, Laakso M112,113,114, Langenberg C3,143, Linneberg A144, Luke A137, Mckenzie CA111, Palotie A10,26,145, Pedersen O31, Peters A120,125, Strauch K116,146, Tayo BO137, Wareham NJ3, Bennett DA57, Bertram L147,148, Blangero J61, Blüher M135,136, Bouchard C99, Campbell H97, Cho NH149, Cummings SR66, Czerwinski SA59, Demuth I102,150, Eckardt R102, Eriksson JG56,67,81, Ferrucci L109, Franco OH91,92, Froguel P53,54,55, Gansevoort RT51, Hansen T31,151, Harris TB72, Hastie N75, Heliövaara M56, Hofman A91,92, Jordan JM87, Jula A56, Kähönen M152,153, Kajantie E56,154,155, Knekt PB56, Koskinen S56, Kovacs P135, Lehtimäki T89,90, Lind L156, Liu Y157, Orwoll ES95, Osmond C158, Perola M10,13,56, Pérusse L159,160, Raitakari OT161,162, Rankinen T99, Rao DC20,104,163, Rice TK104,163, Rivadeneira F65,91,92, Rudan I97, Salomaa V56, Sørensen TI18,31,164, Stumvoll M135,136, Tönjes A136, Towne B59, Tranah GJ66, Tremblay A159, Uitterlinden AG65,91,92, van der Harst P77,165,166, Vartiainen E56, Viikari JS167, Vitart V75, Vohl MC160,168, Völzke H41,169,170, Walker M44,171, Wallaschofski H21,169, Wild S172, Wilson JF75,97, Yengo L53,54,55, Bishop DT23, Borecki IB20,173, Chambers JC36,37,174, Cupples LA30,175, Dehghan A176, Deloukas P25,26,177, Fatemifar G18, Fox C63,175, Furey TS6,178, Franke L77,166, Han J179, Hunter DJ14,28,180,181, Karjalainen J166, Karpe F27,182, Kaplan RC34, Kooner JS37,174,183, McCarthy MI12,27,182, Murabito JM184,185, Morris AP12,186, Bishop JA23, North KE187, Ohlsson C132, Ong KK3,188,189, Prokopenko I12,19,27, Richards JB11,190,191,192, Schadt EE193,194, Spector TD9, Widén E10, Willer CJ35,195,196, Yang J43, Ingelsson E4,5,197, Mohlke KL6, Hirschhorn JN14,15,16, Pospisilik JA198, Zillikens MC65,91, Lindgren C12,14,199, Kilpeläinen TO3,31, Loos RJ1,2,3,200,201.

Author information

1
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
2
The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
3
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
4
Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
5
Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.
6
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
7
Department of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
8
West Herts NHS Trust, Herts HP2 4AD, UK.
9
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
10
Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
11
Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
12
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
13
Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.
14
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
15
Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
16
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
17
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
18
MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
19
Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
20
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
21
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
22
European University of Applied Sciences, Faculty of Applied Public Health, 18055 Rostock, Germany.
23
Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
24
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
25
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
26
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
27
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
28
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
29
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
30
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
31
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
32
Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge 02142, USA.
33
Department of Epidemiology Research, Statens Serum Institut, 2100 Copenhagen, Denmark.
34
Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
35
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
36
Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
37
Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
38
Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.
39
Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
40
Department of Odontology, Umeå University, 901 85 Umeå, Sweden.
41
Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
42
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
43
Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
44
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
45
Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.
46
Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02446, USA.
47
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
48
Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen, 2200 Copenhagen, Denmark.
49
Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, 2200 Copenhagen, Denmark.
50
Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
51
University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
52
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
53
CNRS UMR 8199, F-59019 Lille, France.
54
European Genomic Institute for Diabetes, 59000 Lille, France.
55
Université de Lille 2, 59000 Lille, France.
56
National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
57
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
58
Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden.
59
Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
60
Department of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea.
61
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
62
Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
63
Harvard Medical School, Boston, Massachusetts 02115, USA.
64
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
65
Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
66
California Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
67
Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
68
INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
69
Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
70
Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
71
Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
72
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
73
Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany.
74
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
75
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
76
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
77
University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
78
Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
79
Hospital District of North Karelia, FI-80210 Joensuu, Finland.
80
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland.
81
Folkhälsan Research Centre, FI-00290 Helsinki, Finland.
82
Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland.
83
Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
84
Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA.
85
Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.
86
Max Planck Institute for Human Development, 14194 Berlin, Germany.
87
Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
88
Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore.
89
Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
90
Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland.
91
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
92
Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
93
Department of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden.
94
School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
95
Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
96
Institute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK.
97
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
98
Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland.
99
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
100
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
101
Institute for Anthropological Research, Zagreb 10000, Croatia.
102
The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
103
Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
104
Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
105
EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
106
VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands.
107
Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.
108
Department of Pediatrics, Vaasa Central Hospital, FI-65100 Vaasa, Finland.
109
Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
110
Department of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
111
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
112
Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
113
Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
114
Kuopio University Hospital, 70029 Kuopio, Finland.
115
Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
116
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
117
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
118
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
119
Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
120
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
121
Icelandic Heart Association, Kopavogur 201, Iceland.
122
University of Iceland, Faculty of Medicine, Reykjavik 101, Iceland.
123
Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.
124
Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA.
125
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
126
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
127
Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
128
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
129
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
130
Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA.
131
Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA.
132
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
133
Center for Medical Systems Biology, 2300 Leiden, The Netherlands.
134
Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
135
University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
136
University of Leipzig, Department of Medicine, 04103 Leipzig, Germany.
137
Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
138
German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
139
Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
140
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
141
Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.
142
Research Centre for Prevention and Health, DK2600 Capital Region of Denmark, Denmark.
143
Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
144
Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
145
Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA.
146
Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
147
School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
148
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany.
149
Ajou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea.
150
Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
151
Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
152
Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
153
Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
154
Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.
155
Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland.
156
Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
157
Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
158
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
159
Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
160
Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.
161
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
162
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland.
163
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
164
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark.
165
Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
166
Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
167
Department of Medicine, University of Turku, FI-20521 Turku, Finland.
168
School of Nutrition, Laval University, Québec City, Quebec, Canada G1V 0A6.
169
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
170
DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany.
171
Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.
172
Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
173
Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
174
Imperial College Healthcare NHS Trust, London W12 0HS, UK.
175
National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
176
Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands.
177
Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
178
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
179
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
180
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
181
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
182
Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK.
183
National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
184
Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
185
NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
186
Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
187
Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
188
MRC Unit for Lifelong Health and Ageing at UCL, London WC1B 5JU, UK.
189
Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
190
Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
191
Department of Twin Research, King's College London, London SE1 1E7, UK.
192
Division of Endocrinology, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
193
Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
194
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
195
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
196
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
197
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
198
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany.
199
The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK.
200
The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
201
The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

PMID:
26833246
PMCID:
PMC4740398
DOI:
10.1038/ncomms10495
[Indexed for MEDLINE]
Free PMC Article

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