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Antimicrob Agents Chemother. 2016 Apr 22;60(5):3112-4. doi: 10.1128/AAC.00007-16. Print 2016 May.

Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model.

Author information

1
EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France.
2
EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France Service de Pharmacologie Clinique, Hôpitaux Universitaires Paris Centre Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
3
EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
4
Risk in Pregnancy University Department, Paris, France Service de Gynécologie et Obstétrique, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France Université Paris-Diderot, Paris, France.
5
Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Clinical Pharmaco-Toxicology Department, Hôpitaux Universitaires Paris-Nord Val de Seine, Paris, France IAME, UMR 1137, INSERM, Paris, France.
6
Risk in Pregnancy University Department, Paris, France Service de Gynécologie et Obstétrique, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France Université Paris-Diderot, Paris, France INSERM CESP 1019, Kremlin-Bicêtre, France laurent.mandelbrot@aphp.fr.

Abstract

Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.

PMID:
26833154
PMCID:
PMC4862479
DOI:
10.1128/AAC.00007-16
[Indexed for MEDLINE]
Free PMC Article

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