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Tumori. 1989 Aug 31;75(4):311-20.

Genomic alterations in human breast cancer: a review.

Author information

1
Istituto di Patologia Umana e Medicina Sociale, Università G. D'Annunzio, Chieti, Italy.

Abstract

We review and discuss data on the genetic alterations documented in human breast carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic material (chromosome 11p, 13q, 3p, 1q, 17p); 2) amplification of genes or entire chromosomal segments (c-myc, c-erb-B2, locus DF3/PUM, loci on 11q13); 3) rearrangements (c-myc); 4) point mutations (c-ras). Presently available informations do not allow the development of cohesive pathogenetic models but indicate that the molecular basis of human breast cancer is heterogeneous.

PMID:
2683275
[Indexed for MEDLINE]

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