Send to

Choose Destination
Am J Gastroenterol. 2016 Mar;111(3):372-80. doi: 10.1038/ajg.2016.1. Epub 2016 Feb 2.

High-Resolution Manometry Improves the Diagnosis of Esophageal Motility Disorders in Patients With Dysphagia: A Randomized Multicenter Study.

Author information

Hospices Civils de Lyon, Hopital Edouard Herriot, Explorations Fonctionnelles Digestives and Lyon I University, Lyon, France.
LabTAU, Inserm U1032, Lyon, France.
Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Unité de recherche clinique, and Université de Lyon, EAM 4128 Santé Individu Société, Lyon, France.
CHU Bordeaux, Gastroentérologie and Bordeaux University, Bordeaux, France.
CHU Nantes, Gastroentérologie, and Nantes University, Nantes, France.
CHU Rouen, Physiologie Digestive and Rouen University, Rouen, France.
Assistance Publique Hôpitaux de Paris, Hôpital Louis Mourier, Gastroentérologie, and Paris Diderot University, Colombes, France.
CHU Rennes, Explorations Fonctionnelles Digestives, Rennes, France.



High-resolution manometry (HRM) might be superior to conventional manometry (CM) to diagnose esophageal motility disorders. We aimed to compare the diagnosis performed with HRM and CM and confirmed at 6 months in a multicenter randomized trial.


Patients with unexplained dysphagia were randomized to undergo either CM or HRM. Motility disorders were diagnosed using the Castell and Spechler classification for CM and the Chicago classification for HRM. Diagnosis confirmation was based on clinical outcome and response to treatment after 6-month follow-up. The initial diagnosis and percentage of confirmed diagnoses were compared between the two arms (CM and HRM).


In total, 247 patients were randomized and 245 analyzed: 122 in the CM arm and 123 in the HRM arm. A manometric diagnosis was more frequently initially achieved with HRM than with CM (97% vs. 84%; P<0.01). Achalasia was more frequent in the HRM arm (26% vs. 12% in the CM arm; P<0.01) while normal examinations were more frequent in the CM arm (52% vs. 28% in the HRM arm; P<0.05). After follow-up, the initial diagnosis was confirmed in 89% of patients in the HRM arm vs. 81% in the CM arm (P=0.07). Finally, overall procedure tolerance was better with CM than with HRM (P<0.01).


This randomized trial demonstrated an improved diagnostic yield for achalasia with HRM compared with CM. Diagnoses tended to be more frequently confirmed in patients who underwent HRM, suggesting that esophageal motility disorders could be identified earlier with HRM than with CM (, NCT01284894).

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center