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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Feb;33(1):5-8. doi: 10.3760/cma.j.issn.1003-9406.2016.01.002.

[Application of fluorescent in situ hybridization in primary diagnosis of aplastic anemia by morphology].

[Article in Chinese]

Author information

1
Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China. huanghuif@126.com.

Abstract

OBJECTIVE:

To investigate the clinical application of fluorescent in situ hybridization (FISH) for the differential diagnosis of myelodysplastic syndromes (MDS) and aplastic anemia (AA).

METHODS:

A FISH kit capable of detecting the chromosomal abnormalities related to MDS was used to analyze 94 patients who were suspected to have AA by bone marrow morphology.

RESULTS:

Cytogenetic abnormalities were detected in 11 of the 94 patients, which included trisomy 8 (5 cases), 20q- (1 case) and -Y (1 case). There were 4 cases related to MDS, which included 3 cases of 5q-, in which 1 case carry 20q- at the same time, and 7q- (1 case). No significant difference was found between the MDS and AA groups in terms of age, sex or routine blood examination including absolute neutrophil count, hemoglobin content and platelet count.

CONCLUSION:

FISH can detect certain cytogenetic abnormalities related to MDS in patients morphologically diagnosed as AA.

[Indexed for MEDLINE]

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