Format

Send to

Choose Destination
Food Nutr Res. 2016 Jan 29;60:29857. doi: 10.3402/fnr.v60.29857. eCollection 2016.

Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion.

Author information

1
Farcoderm Srl member of Complife Group, Pavia, Italy; vincenzo.nobile@farcoderm.com.
2
Compagnie des Pêches Saint-Malo Santé, Saint Malo, France.
3
Farcoderm Srl member of Complife Group, Pavia, Italy.
4
Laboratory of Pharmacobiochemistry, Sports Nutrition and Nutriceuticals, University of Pavia, Pavia, Italy.

Abstract

BACKGROUND:

Fish protein hydrolysates (FPHs) have been reported as a suitable source of proteins for human nutrition because of their balanced amino acid composition and positive effect on gastrointestinal absorption.

OBJECTIVE:

Here, we investigated the effect of a FPH, Slimpro(®), obtained from blue whiting (Micromesistius poutassou) muscle by enzymatic hydrolysis, on body composition and on stimulating cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) secretion.

DESIGN:

A randomized clinical study was carried out on 120, slightly overweight (25 kg/m(2) ≤ BMI<30 kg/m(2)), male (25%) and female (75%) subjects. FPH was tested in a food supplement at two doses (1.4 and 2.8 g) to establish if a dose-effect relationship exists. Product use was associated with a mild hypocaloric diet (-300 kcal/day). Body composition (body weight; fat mass; extracellular water; and circumference of waist, thighs, and hips) and CCK/GLP-1 blood levels were measured at the beginning of the study and after 45 and 90 days of product use. CCK/GLP-1 levels were measured since they are involved in controlling food intake.

RESULTS:

Treated subjects reported an improvement of body weight composition and an increased blood concentration of both CCK and GLP-1. No differences were found between the 1.4 and 2.8 g FPH doses, indicating a plateau effect starting from 1.4 g FPH.

CONCLUSIONS:

Both 1.4 and 2.8 g of FPH were effective in improving body composition and in increasing CCK and GLP-1 blood levels.

KEYWORDS:

blue whiting; body composition; body weight; cholecystokinin; clinical study; fish protein hydrolysate; glucagon-like peptide-1; weight management

Supplemental Content

Full text links

Icon for Swedish Nutrition Foundation Icon for PubMed Central
Loading ...
Support Center