Format

Send to

Choose Destination
J Am Coll Surg. 2016 Apr;222(4):534-42. doi: 10.1016/j.jamcollsurg.2015.12.014. Epub 2015 Dec 21.

Elevated Plasma Pancreastatin, but Not Chromogranin A, Predicts Survival in Neuroendocrine Tumors of the Duodenum.

Author information

1
Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA; Neuroendocrine Tumor Program, Ochsner Medical Center, Kenner, LA. Electronic address: ewolte@lsuhsc.edu.
2
Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA.
3
Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA; Neuroendocrine Tumor Program, Ochsner Medical Center, Kenner, LA.
4
Neuroendocrine Tumor Program, Ochsner Medical Center, Kenner, LA.

Abstract

BACKGROUND:

Neuroendocrine tumors (NETs) of the duodenum are rare, heterogeneous, and often indolent neoplasms. We hypothesized that elevated pancreastatin levels are an indicator of a poor prognosis in well-differentiated duodenal NETs.

STUDY DESIGN:

Data from patients diagnosed with a primary duodenal NET were analyzed. Patients that underwent esophogogastroduodenoscopy, endoscopic ultrasound, or exploratory surgery to localize their neoplasm and whose tumors were confirmed histologically were included.

RESULTS:

Eighty-four patients were diagnosed with duodenal NETs from January 1991 to January 2014. Seventy-five percent and 21% of patients had their tumor localized by esophogogastroduodenoscopy and endoscopic ultrasound, respectively. The remaining 4% were localized during exploratory surgery. The 5-year Kaplan-Meier survival rate for the entire cohort (N = 84) was 80%. Survival sorted by normal vs abnormal pancreastatin level was statistically significant (p < 0.0001). Five-year survival rates were 94% and 37% for normal and abnormal pancreastatin, respectively. In contrast, survival sorted by normal vs abnormal plasma chromogranin A level was not statistically significant (p = 0.24).

CONCLUSIONS:

Patients with primary duodenal NETs have high 5-year survival rates. Serial monitoring of plasma pancreastatin levels can identify patients who have a poor prognosis.

Comment in

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center