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J Cyst Fibros. 2016 Sep;15(5):652-9. doi: 10.1016/j.jcf.2016.01.003. Epub 2016 Jan 28.

Reversible airway obstruction in cystic fibrosis: Common, but not associated with characteristics of asthma.

Author information

1
Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
2
CF Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Hebrew University Hadassah Medical School, Jerusalem, Israel.
3
Hebrew University Hadassah Medical School, Jerusalem, Israel.
4
Clalit research institute, Clalit health services, Tel-Aviv, Israel.
5
Pulmonary Institute and Graub Cystic Fibrosis Center, Schneider Children's Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. Electronic address: hblau@post.tau.ac.il.

Abstract

BACKGROUND:

As asthma-like symptoms are common in CF, we evaluated reversible airway obstruction and associated characteristics.

METHODS:

Retrospective analysis of charts including spirometry and bronchodilator response.

RESULTS:

Of 190 CF patients (103 at Schneider's, 87 at Hadassah), aged 14.4 (4-76) years, median (range), 39% had reversible obstruction (ΔFEV1% predicted ≥12%), associated with younger age (p=0.01) and severe genotype (p=0.02). There was no association with family history of asthma, serum IgE, blood eosinophils, pancreatic status, FEV1<40% predicted, Aspergillus or pseudomonas infection. Of patients with reversible obstruction, 74% were on bronchodilator and 68% on inhaled corticosteroid therapy but 54% and 57% respectively receiving these therapies did not have reversible obstruction.

CONCLUSIONS:

Reversible airway obstruction is common in CF, more frequent in younger patients and with severe genotype, with no correlation to markers of atopy or CF clinical severity. Bronchodilator and inhaled corticosteroid therapies are commonly prescribed even without reversible obstruction.

KEYWORDS:

Airway obstruction; Asthma; Bronchodilator; Cystic fibrosis; Hyperreactivity; Reversibility

PMID:
26826913
DOI:
10.1016/j.jcf.2016.01.003
[Indexed for MEDLINE]
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