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Curr Opin Genet Dev. 2016 Apr;37:76-81. doi: 10.1016/j.gde.2015.12.003. Epub 2016 Jan 27.

Pioneer transcription factors, chromatin dynamics, and cell fate control.

Author information

1
Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 9-131 SCTR, 3400 Civic Center Blvd., Philadelphia, PA 19104-5157, USA. Electronic address: zaret@upenn.edu.
2
Department of Molecular and Cellular Biology, Harvard University, BL3015, 16 Divinity Ave, Cambridge, MA 02139, USA.

Abstract

Among the diverse transcription factors that are necessary to elicit changes in cell fate, both in embryonic development and in cellular reprogramming, a subset of factors are capable of binding to their target sequences on nucleosomal DNA and initiating regulatory events in silent chromatin. Such 'pioneer transcription factors' initiate cooperative interactions with other regulatory proteins to elicit changes in local chromatin structure. As a consequence of pioneer factor binding, the local chromatin can either become open and competent for activation, closed and repressed, or transcriptionally active. Understanding how pioneer factors initiate chromatin dynamics and how such can be blocked at heterochromatic sites provides insights into controlling cell fate transitions at will.

PMID:
26826681
PMCID:
PMC4914445
DOI:
10.1016/j.gde.2015.12.003
[Indexed for MEDLINE]
Free PMC Article

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