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Curr Opin Virol. 2016 Apr;17:45-9. doi: 10.1016/j.coviro.2016.01.006. Epub 2016 Jan 27.

Antibody therapeutics for Ebola virus disease.

Author information

  • 1Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd #C105, San Diego, CA 92121, USA. Electronic address: larry.zeitlin@mappbio.com.
  • 2Mapp Biopharmaceutical, Inc., 6160 Lusk Blvd #C105, San Diego, CA 92121, USA.
  • 3Integrated Research Facility, 8200 Research Plaza Frederick, MD 21702, USA.
  • 4Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, United Kingdom.
  • 5High Containment Microbiology Department, National Infections Service, Public Health England, 61 Colindale Avenue, London NW9 5HT, United Kingdom.
  • 6Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada.
  • 7Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada; Department of Immunology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada.

Abstract

With the unprecedented scale of the 2014-2016 West Africa outbreak, the clinical and scientific community scrambled to identify potential therapeutics for Ebola virus disease (EVD). Passive administration of antibodies has a long successful history for prophylaxis and therapy of a variety of infectious diseases, but the importance of antibodies in EVD has been unclear and is the subject of some debate. Recent studies in non-human primates have renewed interest in the potential of antibodies to impact EVD. Currently ongoing clinical evaluation of polyclonal and monoclonal antibody therapy in EVD patients in West Africa may finally offer a definitive answer to this debate.

PMID:
26826442
PMCID:
PMC4902774
[Available on 2017-04-01]
DOI:
10.1016/j.coviro.2016.01.006
[PubMed - in process]
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