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Autoimmun Rev. 2016 May;15(5):484-6. doi: 10.1016/j.autrev.2016.01.019. Epub 2016 Jan 28.

Hypothyroidism among SLE patients: Case-control study.

Author information

1
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler; Faculty of Medicine, Tel-Aviv University, Israel.
2
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler.
3
Chief Physician's Office, Clalit Health Services Tel Aviv, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
4
Chief Physician's Office, Clalit Health Services Tel Aviv, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
5
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler; Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: howard.amital@sheba.health.gov.il.

Abstract

BACKGROUND:

The prevalence of hypothyroidism in SLE patients varies considerably and early reports were mainly based on small cohorts.

OBJECTIVES:

To investigate the association between SLE and hypothyroidism.

METHODS:

Patients with SLE were compared with age and sex-matched controls regarding the proportion of hypothyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services.

RESULTS:

The study included 5018 patients with SLE and 25,090 age and sex-matched controls. The proportion of hypothyroidism in patients with SLE was increased compared with the prevalence in controls (15.58% and 5.75%, respectively, P<0.001). In a multivariate analysis, SLE was associated with hypothyroidism (odds ratio 2.644, 95% confidence interval 2.405-2.908).

CONCLUSIONS:

Patients with SLE have a greater proportion of hypothyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of the possibility of thyroid dysfunction.

KEYWORDS:

Autoimmune disease; Hypothyroidism; Polyautoimmunity; SLE; Thyroid dysfunction

PMID:
26826435
DOI:
10.1016/j.autrev.2016.01.019
[Indexed for MEDLINE]

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