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Prog Cardiovasc Dis. 2016 Mar-Apr;58(5):537-47. doi: 10.1016/j.pcad.2016.01.008. Epub 2016 Jan 28.

Obesity and Prevalence of Cardiovascular Diseases and Prognosis-The Obesity Paradox Updated.

Author information

1
Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA. Electronic address: clavie@ochsner.org.
2
Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA.
3
Veterans Affairs Medical Center, Cardiology Department, Georgetown University School of Medicine, Washington, DC, USA.
4
PROFITH "PROmoting FITness and Health through Physical Activity" Research Group, Department of Physical Education and Sports, Faculty of Sports Sciences, University of Granada, Granada, Spain.
5
Department of Physical Therapy, Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, College of Applied Science, University of Illinois at Chicago, Chicago, IL, USA.

Abstract

The prevalence and severity of obesity have increased in the United States and most of the Westernized World over recent decades, reaching worldwide epidemics. Since obesity worsens most of the cardiovascular disease (CVD) risk factors, not surprisingly, most CVDs, including hypertension, coronary heart disease, heart failure, and atrial fibrillation, are all increased in the setting of obesity. However, many studies and meta-analyses have demonstrated an obesity paradox with regards to prognosis in CVD patients, with often the overweight and mildly obese having a better prognosis than do their leaner counterparts with the same CVD. The implication for fitness to markedly alter the relationship between adiposity and prognosis and the potential impact of weight loss, in light of the obesity paradox, are all reviewed.

KEYWORDS:

Cardiorespiratory fitness; Cardiovascular diseases; Obesity; Weight loss

PMID:
26826295
DOI:
10.1016/j.pcad.2016.01.008
[Indexed for MEDLINE]
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