Format

Send to

Choose Destination
Am J Physiol Cell Physiol. 2016 Apr 15;310(8):C625-8. doi: 10.1152/ajpcell.00292.2015. Epub 2016 Jan 28.

Pivotal role of AKAP121 in mitochondrial physiology.

Author information

1
Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida.
2
Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida nkollipu@health.usf.edu.

Abstract

In this Perspective, we discuss some recent developments in the study of the mitochondrial scaffolding protein AKAP121 (also known as AKAP1, or AKAP149 as the human homolog), with an emphasis on its role in mitochondrial physiology. AKAP121 has been identified to function as a key regulatory molecule in several mitochondrial events including oxidative phosphorylation, the control of membrane potential, fission-induced apoptosis, maintenance of mitochondrial Ca(2+)homeostasis, and the phosphorylation of various mitochondrial respiratory chain substrate molecules. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death.

KEYWORDS:

AKAP1; AKAP121; apoptosis; dysfunction; mitochondria

PMID:
26825124
PMCID:
PMC4835917
DOI:
10.1152/ajpcell.00292.2015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center