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Cell. 2016 Jan 28;164(3):341-2. doi: 10.1016/j.cell.2016.01.006.

Epigenetic ON/OFF Switches for Obesity.

Author information

1
Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany.
2
Institute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany; IGBMC, Strasbourg, 67400 Illkirch, France.
3
Helmholtz Diabetes Center & German Diabetes Center (DZD), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany. Electronic address: tschoep@helmholtz-muenchen.de.

Abstract

Heritable epigenetic mechanisms might contribute to the worldwide increase in the prevalence of obesity. Dalgaard et al. identify an epigenetic molecular switch that controls body weight control. The discovery suggests the existence of mammalian polyphenism in energy metabolism and might have implications for strategies to limit the obesity epidemic.

PMID:
26824648
DOI:
10.1016/j.cell.2016.01.006
[Indexed for MEDLINE]
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