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ACS Appl Mater Interfaces. 2016 Feb;8(7):4407-15. doi: 10.1021/acsami.5b10885. Epub 2016 Feb 9.

How Leucocyte Cell Membrane Modified Janus Microcapsules are Phagocytosed by Cancer Cells.

Author information

1
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Centre, Harbin Institute of Technology , Yikuang Street 2 B1, Harbin 150080, China.

Abstract

Modern drug delivery systems rely on either antibody-based single-surface recognition or on surface-hydrophobicity-based approaches. For a tumor showing various surface mutations, both approaches fail. This publication hereby presents Janus capsules based on polyelectrolyte multilayer microcapsules exhibiting human leucocyte (THP-1 cell line) cell membranes for discriminating HUVEC cells from three different cancer cell lines. Despite destroying the cellular integrity of leucocyte cells, the modified Janus capsules are able to adhere to cancer cells. Leucocyte cell-membrane-coated Janus capsules are phagocytosed with the cellular membrane part pointing to the cells.

KEYWORDS:

Janus capsule; biocompatible; leukocyte cell; phagocytosis; target recognition

PMID:
26824329
DOI:
10.1021/acsami.5b10885
[Indexed for MEDLINE]

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