Format

Send to

Choose Destination
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15260-4. eCollection 2015.

Short-term effects of splenectomy on serum fibrosis indexes in liver cirrhosis patients.

Author information

1
Department of General Surgery, Capital Medical University Affiliated Beijing Youan Hospital Beijing 100069, China.
2
The Fifth Hospital of Shijiazhuang Shijiazhuang, China.
3
Institute & Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital Beijing 100853, China.

Abstract

OBJECTIVE:

To determine the changing patterns of 4 liver fibrosis markers pre and post splenectomy (combined with pericardial devascularization [PCDV]) and to examine the short-term effects of splenectomy on liver fibrosis.

METHODS:

Four liver fibrosis markers of 39 liver cirrhosis patients were examined pre, immediately post, 2 days post, and 1 week post (15 cases) splenectomy (combined with PCDV).

RESULTS:

The laminin (LN) level decreased immediately post surgery compared with the preoperative LN level (P < 0.05). The type IV collagen level decreased immediately post surgery compared with that pre surgery (P < 0.05), it significantly increased (P < 0.05) 2 days post surgery and significantly decreased 1 week post surgery (P < 0.05). Hyaluronic acid and the procollagen III N-terminal peptide levels increased significantly 2 days post surgery compared with that pre and immediately post surgery, they significantly decreased 1 week post surgery compared to 2 days post surgery (P < 0.05).

CONCLUSIONS:

In the short-term, the 4 liver fibrosis markers and the FibroScans post splenectomy showed characteristic changes, splenectomy may transiently initiate the degradation process of liver fibrosis.

KEYWORDS:

4 liver fibrosis markers; Splenectomy; liver cirrhosis

PMID:
26823877
PMCID:
PMC4713663
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center