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Neurosci Lett. 1989 Jul 31;102(2-3):137-41.

The neuronal response to injury as visualized by immunostaining of class III beta-tubulin in the rat.

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Department of Cell Biology and Anatomy, Neurobiology Research Center, University of Alabama, Birmingham 35294.


The neuronal response to trauma of the brain and spinal cord was examined by staining sections of injured central nervous system (CNS) with a monoclonal antibody (TuJ1) that recognizes class III beta-tubulin exclusively. Because class III beta-tubulin is expressed by neurons and not by glia, this monoclonal antibody stains neuronal cell bodies, dendrites, axons and axonal terminations darkly with a pale staining background. Thus, the TuJ1 antibody is extremely useful, revealing the fine details of axons and their terminations, as well as significant injury-related alterations in the composition of the somatic cytoskeleton.

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