Format

Send to

Choose Destination
J Vet Intern Med. 2016 Mar-Apr;30(2):636-41. doi: 10.1111/jvim.13827. Epub 2016 Jan 29.

The Effect of the Canine ABCB1-1Δ Mutation on Sedation after Intravenous Administration of Acepromazine.

Author information

1
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
2
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA.
3
Veterinary Health Research, Waikato Innovation Park, Hamilton, New Zealand.

Abstract

BACKGROUND:

Dog breeds with the ABCB1-1Δ mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut/mut dogs showed increased depth and duration of acepromazine sedation.

HYPOTHESIS/OBJECTIVES:

That ABCB1 mut/mut dogs have increased depth and duration of sedation after acepromazine IV compared to normal dogs (nor/nor).

ANIMALS:

Twenty-nine rough-coated collies were divided into 3 groups of dogs based on their ABCB1 genotype: 10 mut/mut, 10 mut/nor, and 9 nor/nor.

METHODS:

Dogs were given 0.04 mg/kg of acepromazine IV. Level of sedation, heart rate, respiratory rate, and blood pressure were recorded for 6 hours after acepromazine administration. Area under the curves (AUCs) of the normalized sedation score results were calculated and compared.

RESULTS:

The median sedation scores for ABCB1 mut/mut dogs were higher than nor/nor dogs at all time points and were higher in mut/nor dogs for the first 2 hours. These differences were not found to be significant for any individual time point (P > .05). The median sedation score AUC for mut/mut dogs was significantly higher than nor/nor dogs (P = .028), but the AUC for mut/nor dogs was not (P = .45). There were no significant differences between groups for heart rate, respiratory rate, and blood pressure (P > .05).

CONCLUSIONS AND CLINICAL IMPORTANCE:

In ABCB1 mut/mut dogs acepromazine dose rates should be reduced and careful monitoring performed during sedation.

KEYWORDS:

Collie; MDR1; P-glycoprotein

PMID:
26822006
PMCID:
PMC4913601
DOI:
10.1111/jvim.13827
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center