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Curr Opin Genet Dev. 2016 Apr;37:46-50. doi: 10.1016/j.gde.2015.12.005. Epub 2016 Jan 26.

Systematic approaches to identify functional lncRNAs.

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA; Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.
2
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. Electronic address: ttsukiya@fhcrc.org.

Abstract

Long noncoding RNAs (lncRNAs) were discovered in eukaryotes more than 30 years ago [1]. Recent advances in genomics have led to the discovery that lncRNAs are transcribed pervasively across the genome [2(•),3,4,5(•)]. There are an increasing number of reports that identify lncRNAs whose expression is modulated during cell differentiation or in disease states. However, biological functions for the vast majority of them are yet to be determined. Here, we propose two ways to identify lncRNAs that have biological functions: to identify lncRNAs with dedicated preinitiation complexes (PICs), and to focus on those whose transcription is highly regulated.

PMID:
26821363
PMCID:
PMC4914422
DOI:
10.1016/j.gde.2015.12.005
[Indexed for MEDLINE]
Free PMC Article

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