Format

Send to

Choose Destination
Genes (Basel). 2016 Jan 26;7(2). pii: E7. doi: 10.3390/genes7020007.

The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection.

Wang Y1,2, Wang Z3, Chen X4, Zhang H5, Guo F6,7, Zhang K8, Feng H9, Gu W10, Wu C11, Ma L12, Li T13, Chen C14, Gao S15.

Author information

1
College of Medicine, Shihezi University, Xinjiang 832000, China. a201511281@126.com.
2
Co-Innovation Center for Zoonotic Infectious Diseases in the western region, Shihezi University, Xinjiang 832000, China. a201511281@126.com.
3
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. b201511281@126.com.
4
College of Life Sciences, Nankai University, Tianjin 300071, China. c201511281@126.com.
5
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. zhanghui@shzu.edu.cn.
6
College of Medicine, Shihezi University, Xinjiang 832000, China. d201511281@126.com.
7
Co-Innovation Center for Zoonotic Infectious Diseases in the western region, Shihezi University, Xinjiang 832000, China. d201511281@126.com.
8
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. e201511281@126.com.
9
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. f201511281@126.com.
10
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. g201511281@126.com.
11
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. h201511281@126.com.
12
College of Life Sciences, Shihezi University, Xinjiang 832000, China. i201511281@126.com.
13
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. j201511281@126.com.
14
College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China. chenchuangfu@shzu.edu.cn.
15
College of Life Sciences, Nankai University, Tianjin 300071, China. gao_shan@mail.nankai.edu.cn.

Abstract

Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608.

KEYWORDS:

B. suis 019; Brucella; comparative genomics; complete genome; cross species

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center