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Biol Aujourdhui. 2015;209(3):261-72. doi: 10.1051/jbio/2015024. Epub 2016 Jan 28.

[The role of sleep in memory consolidation: effects of age and Alzheimer's disease].

[Article in French]

Author information

1
Inserm U1077, GIP Cyceron, Bd Becquerel, BP 5229, 14074 Caen Cedex 5, France - Université de Caen Normandie, UMR-S1077, Caen, France - École Pratique des Hautes Études, UMR-S1077, Caen, France - CHU de Caen, U1077, Caen, France.

Abstract

Sleep favors memory consolidation. Studies conducted in recent years allowed to reveal the neurobiological underpinnings underlying the beneficial effect of sleep on memory. They also have led to the proposal of two theoretical models: the "hippocampo-neocortical dialogue" and the "synaptic downscaling hypothesis". Normal ageing and, even more markedly Alzheimer's disease, are associated with sleep changes that may alter sleep-dependent memory consolidation. This paper presents a review of studies investigating the relationships between sleep and memory and how these links are affected by ageing and Alzheimer's disease.

PMID:
26820832
DOI:
10.1051/jbio/2015024
[Indexed for MEDLINE]

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