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World J Gastroenterol. 2016 Jan 28;22(4):1477-86. doi: 10.3748/wjg.v22.i4.1477.

Host restriction factors for hepatitis C virus.

Author information

1
Li-Ya Zhou, Lei-Liang Zhang, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China.

Abstract

Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.

KEYWORDS:

Entry; Hepatitis C virus; Host restriction factor; Interferon; Propagation; Replication

PMID:
26819515
PMCID:
PMC4721981
DOI:
10.3748/wjg.v22.i4.1477
[Indexed for MEDLINE]
Free PMC Article

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