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Jpn J Clin Oncol. 2016 Apr;46(4):310-5. doi: 10.1093/jjco/hyv210. Epub 2016 Jan 26.

Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients.

Author information

1
Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum tatsuro@yamaguchi.email.ne.jp.
2
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama.
3
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgery, National Defense Medical College, Saitama.
4
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo.
5
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima.
6
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie.
7
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama.
8
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Colorectal Surgery Division, National Cancer Center Hospital, Tokyo.
9
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.
10
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgery, Hyogo College of Medicine, Hyogo.
11
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo.
12
Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

OBJECTIVE:

The upper gastrointestinal characteristics in Japanese familial adenomatous polyposis patients have not yet been clarified. The aim of the present study was to elucidate these characteristics in Japanese familial adenomatous polyposis patients.

METHODS:

This study was conducted by the study group for familial adenomatous polyposis in the Japanese Society for Cancer of the Colon and Rectum. Familial adenomatous polyposis patients who underwent surgical resection from 2000 to 2012 were included in the study.

RESULTS:

In total, 303 familial adenomatous polyposis patients were enrolled, with 265 cases of classical familial adenomatous polyposis (≥100 adenomas) and 38 cases of attenuated familial adenomatous polyposis (<100 adenomas). Fundic gland polyps were significantly more common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis; however, gastric cancer was significantly less common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis. Gastric cancer and duodenal adenoma were significantly more common in familial adenomatous polyposis patients with gastric adenoma than in those without gastric adenoma. Duodenal cancer was detected in 7 of 72 familial adenomatous polyposis patients with duodenal adenoma. The median tumour risk in 50-year-old familial adenomatous polyposis patients was 55.3, 21.8, 3.8, 39.2 and 7.7% for fundic gland polyp, gastric adenoma, gastric cancer, duodenal adenoma and duodenal cancer, respectively.

CONCLUSIONS:

Upper gastrointestinal tumours/polyps were frequently found in familial adenomatous polyposis patients, and their incidences were correlated; however, the frequency of gastric cancer in Japanese familial adenomatous polyposis patients was similar to that in the general population.

KEYWORDS:

duodenal adenoma; duodenal cancer; familial adenomatous polyposis; fundic gland polyp; gastric adenoma; gastric cancer

PMID:
26819281
PMCID:
PMC4886134
DOI:
10.1093/jjco/hyv210
[Indexed for MEDLINE]
Free PMC Article

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