New therapeutic approaches for the treatment of obesity

Sci Transl Med. 2016 Jan 27;8(323):323rv2. doi: 10.1126/scitranslmed.aad1811.

Abstract

This review discusses current and future pharmacological approaches to the treatment of obesity, with a focus on the biological control of energy balance.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Anti-Obesity Agents
  • Bile Acids and Salts / chemistry
  • Body Weight
  • Diabetes Mellitus, Type 2 / complications
  • Drug Discovery
  • Energy Metabolism
  • Feeding Behavior
  • Homeostasis
  • Humans
  • Hypothalamus / metabolism
  • Inflammation / complications
  • Leptin / chemistry
  • Obesity / complications
  • Obesity / therapy*
  • Oxidative Phosphorylation
  • Pediatric Obesity / therapy*

Substances

  • Anti-Obesity Agents
  • Bile Acids and Salts
  • Leptin