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Nat Commun. 2016 Jan 28;7:10531. doi: 10.1038/ncomms10531.

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

Author information

1
Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
2
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
3
Laboratory for Omics Informatics, Omics Research Center, National Cerebral And Cardiovascular Center, Suita 565-8565, Japan.
4
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
5
Department of Diabetes Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo 160-0023, Japan.
6
Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
7
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
8
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.
9
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore.
10
Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico.
11
Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
12
Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea.
13
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.
14
Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
15
Center for Non-Communicable Diseases, Karachi, Pakistan.
16
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
17
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
18
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
19
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
20
Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
21
First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
22
Health Administration Center, University of Toyama, Toyama 930-0194, Japan.
23
Department of Public Health and Primary Care, University of Cambridge CB1 8RN, UK.
24
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1RQ, UK.
25
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
26
Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup DK-2600, Denmark.
27
Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen 2200, Denmark.
28
Faculty of Medicine, University of Aalborg, Aalborg 9220, Denmark.
29
Steno Diabetes Center, Gentofte 2820, Denmark.
30
Department of Public Health, Aarhus University, Aarhus 8000, Denmark.
31
Danish Diabetes Academy, Odense 5000, Denmark.
32
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle 7100, Denmark.
33
Institute of Regional Health Research, University of Southern Denmark, Odense 5230, Denmark.
34
Medical Department, Lillebaelt Hospital, Vejle 7100, Denmark.
35
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
36
Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona 08034, Spain.
37
Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
38
Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
39
Universidad Autónomas Metropolitana, Mexico City 09340, Mexico.
40
Central University of Punjab, Bathinda, Punjab 151001, India.
41
Health Center, Keio University, Tokyo 160-8582, Japan.
42
Department of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.
43
Grand Tower Medical Court Life Care Clinic, Hiroshima 730-0012, Japan.
44
Department of Internal Medicine, Kawasaki Medical School, Kurashiki 701-0192, Japan.
45
Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
46
Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-0034, Japan.
47
Division of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki 216-8511, Japan.
48
RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
49
Department of Biomedical Science, Hallym University, Chunchon, Gangwon-do 24252, Republic of Korea.
50
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
51
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, n.
52
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
53
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
54
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
55
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
56
Duke-National University of Singapore Graduate School, Singapore 169857, Singapore.
57
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan.
58
Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara 903-0215, Japan.

Abstract

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

PMID:
26818947
PMCID:
PMC4738362
DOI:
10.1038/ncomms10531
[Indexed for MEDLINE]
Free PMC Article

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