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J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):968-74. doi: 10.1136/jnnp-2015-311298. Epub 2016 Jan 27.

Task-specific dystonia: pathophysiology and management.

Author information

1
Sobell Department for Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.
2
Department of Neurology, Boston University, Boston, Massachusetts, USA.
3
Department of Neurology, San Carlos Health Research Institute (IdISSC) Universidad Complutense de Madrid, Madrid, Spain.
4
Department of Neurology, University Medical Centre Groningen, Groningen, The Netherlands.
5
Faculty of Health and Human Sciences, Plymouth University, Plymouth, UK.
6
Institute of Cardiovascular and Cell Sciences, St George's University, London, UK.

Abstract

Task-specific dystonia is a form of isolated focal dystonia with the peculiarity of being displayed only during performance of a specific skilled motor task. This distinctive feature makes task-specific dystonia a particularly mysterious and fascinating neurological condition. In this review, we cover phenomenology and its increasingly broad-spectrum risk factors for the disease, critically review pathophysiological theories and evaluate current therapeutic options. We conclude by highlighting the unique features of task-specific dystonia within the wider concept of dystonia. We emphasise the central contribution of environmental risk factors, and propose a model by which these triggers may impact on the motor control of skilled movement. By viewing task-specific dystonia through this new lens which considers the disorder a modifiable disorder of motor control, we are optimistic that research will yield novel therapeutic avenues for this highly motivated group of patients.

KEYWORDS:

DYSTONIA

PMID:
26818730
DOI:
10.1136/jnnp-2015-311298
[Indexed for MEDLINE]

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