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Nutr J. 2016 Jan 27;15:11. doi: 10.1186/s12937-016-0128-2.

Oral hyaluronan relieves knee pain: a review.

Author information

1
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. mariko_oe@kewpie.co.jp.
2
Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjyuku-ku, Tokyo, Japan. tsyktashiro@yahoo.co.jp.
3
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. hideto_yoshida@kewpie.co.jp.
4
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. hiroshi_nishiyama@kewpie.co.jp.
5
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan. yasunobu_masuda@kewpie.co.jp.
6
Gate Town Hospital, 1-6-19, Sekimachi-kita, Nerima-ku, Tokyo, Japan. gthsplab@sweet.ocn.ne.jp.
7
Shiba Palace Clinic, 1-9-10 Hamamatsucho, Minato-ku, Tokyo, Japan. shiba_palace@s-palace-clinic.com.
8
SOUKEN Corporation, 1-9-10, Hamamatsu-cho, Minato-ku, Tokyo, Japan. maruya@souken-lab.co.jp.
9
Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan. n-fukui@idaten.c.u-tokyo.ac.jp.

Abstract

Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.

PMID:
26818459
PMCID:
PMC4729158
DOI:
10.1186/s12937-016-0128-2
[Indexed for MEDLINE]
Free PMC Article

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