Format

Send to

Choose Destination
Am J Cardiovasc Drugs. 2016 Jun;16(3):153-61. doi: 10.1007/s40256-016-0160-9.

How May Proton Pump Inhibitors Impair Cardiovascular Health?

Author information

1
Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA.
2
Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA. jpcooke@houstonmethodist.org.

Abstract

Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.

PMID:
26817947
PMCID:
PMC4864131
DOI:
10.1007/s40256-016-0160-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center