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Transl Androl Urol. 2015 Jun;4(3):381-90. doi: 10.3978/j.issn.2223-4683.2015.06.02.

Advances in the treatment of testicular cancer.

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1 Department of Urology, Rabin Medical Centre Beilinson Campus, Petah Tiqwa, Israel ; 2 Sackler Medical School, Tel Aviv University, P.O. Box 39040, Tel Aviv 69978, Israel.


Germ cell tumors (GCT) are relatively uncommon, accounting for only 1% of male malignancies in the United States. It has become an important oncological disease for several reasons. It is the most common malignancy in young men 15-35 years old. GCTs are among a unique numbers of neoplasms where biochemical markers play a critical role. Finally, it is a model of curable cancer. In this review we discuss cancer epidemiology, genetics, and therapeutic principles. Recent advances in the management of stage I GCT and controversies in the management of post chemotherapy residual mass are presented.


Neoplasms germ cell tumor; chemotherapy; chemotherapy adjuvant; incidence; lymph node excision; neoplasm staging; orchiectomy; patient selection; treatment outcome

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