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J Am Heart Assoc. 2016 Jan 26;5(1). pii: e002503. doi: 10.1161/JAHA.115.002503.

Consumption of Caffeinated Products and Cardiac Ectopy.

Author information

1
University of California, San Francisco, San Francisco, CA (S.D., J.W.D., E.V., G.M.M.).
2
Washington University School of Medicine, St. Louis, MO (P.K.S.).
3
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR (T.A.D.).
4
University of Washington and Group Health Research Institute, Seattle, WA (S.R.H.).

Abstract

BACKGROUND:

Premature cardiac contractions are associated with increased morbidity and mortality. Though experts associate premature atrial contractions (PACs) and premature ventricular contractions (PVCs) with caffeine, there are no data to support this relationship in the general population. As certain caffeinated products may have cardiovascular benefits, recommendations against them may be detrimental.

METHODS AND RESULTS:

We studied Cardiovascular Health Study participants with a baseline food frequency assessment, 24-hour ambulatory electrocardiography (Holter) monitoring, and without persistent atrial fibrillation. Frequencies of habitual coffee, tea, and chocolate consumption were assessed using a picture-sort food frequency survey. The main outcomes were PACs/h and PVCs/hour. Among 1388 participants (46% male, mean age 72 years), 840 (61%) consumed ≥1 caffeinated product per day. The median numbers of PACs and PVCs/h and interquartile ranges were 3 (1-12) and 1 (0-7), respectively. There were no differences in the number of PACs or PVCs/h across levels of coffee, tea, and chocolate consumption. After adjustment for potential confounders, more frequent consumption of these products was not associated with ectopy. In examining combined dietary intake of coffee, tea, and chocolate as a continuous measure, no relationships were observed after multivariable adjustment: 0.48% fewer PACs/h (95% CI -4.60 to 3.64) and 2.87% fewer PVCs/h (95% CI -8.18 to 2.43) per 1-serving/week increase in consumption.

CONCLUSIONS:

In the largest study to evaluate dietary patterns and quantify cardiac ectopy using 24-hour Holter monitoring, we found no relationship between chronic consumption of caffeinated products and ectopy.

KEYWORDS:

arrhythmia; diet; electrophysiology; epidemiology

PMID:
26813889
PMCID:
PMC4859368
DOI:
10.1161/JAHA.115.002503
[Indexed for MEDLINE]
Free PMC Article

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