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Evolution. 2016 Mar;70(3):707-15. doi: 10.1111/evo.12867. Epub 2016 Feb 11.

Evolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.

Author information

  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, 63110. Elizabeth.Atkinson@stonybrook.edu.
  • 2Current Address: Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, 11794. Elizabeth.Atkinson@stonybrook.edu.
  • 3Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030.
  • 4Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, 63110.

Abstract

Bilateral symmetry is a fundamental property of the vertebrate central nervous system. Local deviations from symmetry provide various types of information about the development, evolution, and function of elements within the CNS, especially the cerebral hemispheres. Here, we quantify the pattern and extent of asymmetry in cortical folding within the cerebrum of Papio baboons and assess the evolutionary and developmental implications of the findings. Analyses of directional asymmetry show a population-level trend in length measurements indicating that baboons are genetically predisposed to be asymmetrical, with the right side longer than the left in the anterior cerebrum while the left side is longer than the right posteriorly. We also find a corresponding bias to display a right frontal petalia (overgrowth of the anterior pole of the cerebral cortex on the right side). By quantifying fluctuating asymmetry, we assess canalization of brain features and the susceptibility of the baboon brain to developmental perturbations. We find that features are differentially canalized depending on their ontogenetic timing. We further deduce that development of the two hemispheres is to some degree independent. This independence has important implications for the evolution of cerebral hemispheres and their separate specialization. Asymmetry is a major feature of primate brains and is characteristic of both brain structure and function.

KEYWORDS:

Baboon; developmental noise; gyrification; morphological integration; primate brain evolution

PMID:
26813679
PMCID:
PMC4801758
[Available on 2017-03-01]
DOI:
10.1111/evo.12867
[PubMed - indexed for MEDLINE]
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