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Diabetes Care. 2016 Mar;39(3):469-71. doi: 10.2337/dc15-2011. Epub 2016 Jan 26.

Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women.

Author information

1
Department of Public Health Sciences, Clemson University, Clemson, SC liweic@clemson.edu.
2
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
3
Department of Public Health, and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN.
4
Department of Nutrition, Harvard School of Public Health, Boston, MA Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard School of Public Health, Boston, MA.

Abstract

OBJECTIVE:

To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM).

RESEARCH DESIGN AND METHODS:

A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II.

RESULTS:

The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95-1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI.

CONCLUSIONS:

These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

PMID:
26813668
PMCID:
PMC4764040
[Available on 2017-03-01]
DOI:
10.2337/dc15-2011
[Indexed for MEDLINE]
Free PMC Article

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