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J Nutr Health Aging. 2016 Feb;20(2):185-91. doi: 10.1007/s12603-015-0570-4.

Effects of Nutritional Supplements on Muscle Mass and Activities of Daily Living in Elderly Rehabilitation Patients with Decreased Muscle Mass: A Randomized Controlled Trial.

Author information

1
Yoshihiro Yoshimura, Kumamoto Rehabilitation Hospital, Dept. of Rehabilitation Medicine, 760 Magate, Kikuyo-machi, Kikuchi, Kumamoto 869-1106, Japan, hanley.belfus@gmail.com.

Abstract

OBJECTIVE:

To investigate the effects of nutritional intervention with resistance training on skeletal muscle mass in elderly patients with disabilities in a convalescent rehabilitation setting.

DESIGN:

A randomized controlled trial. (UMIN Clinical Trials Registry ID: UMIN000006238).

SETTING:

A rehabilitation hospital.

PARTICIPANTS:

39 elderly patients with decreased skeletal muscle mass in an inpatient convalescence rehabilitation unit.

INTERVENTIONS:

A combination of resistance training plus nutritional supplementation (R/N group) or resistance training alone (R group). The training and supplementation were conducted essentially from the patient's admission to discharge (2-6 months).

OUTCOME MEASURES:

The patients were evaluated at the time of admission and at the end of the intervention for skeletal muscle mass (calf circumference [CC] as a primary outcome, and arm circumference [AC]), hand grip strength (HG), Mini-Nutritional Assessment-Short Form (MNA®-SF) score, serum albumin level (Alb), body mass index (BMI), and activities of daily living (ADL) as represented by the Barthel Index (BI) score.

RESULTS:

Significant treatment effects were seen for CC, AC, BI, Alb in the R/N group compared to the R group. A mean treatment effect of 3.2 (95%CI: 2.0-4.4) was seen in CC, 1.4 (95%CI: 0.8-2.1) was seen in AC, 11.2 (95%CI: 0.5-21.8) was seen in BI, 0.3 (95%CI: 0.1-0.5) was seen in Alb.

CONCLUSION:

The results of this study suggest that nutritional intervention added to resistance training during convalescent rehabilitation may improve skeletal muscle mass and activities of daily living.

PMID:
26812515
DOI:
10.1007/s12603-015-0570-4
[Indexed for MEDLINE]

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